Liquisolid compacts of ketoprofen patch

Ketoprofen topical patch 20% in the treatment of pain associated with shoulder, elbow or knee tendonitis or bursitis. Ketoprofen is contraindicated for the treatment of perioperative pain in the setting of cabg surgery. The main metabolite of ketoprofen is the pharmacologically inactive glucuronide conjugate. Preparation and in vitro evaluation of ketoprofen solid. Ahuja a et al the pharmaceutical and chemical journal, 2016, 34.

Transdermal patch is a very simple and painless method for providing postoperative analgesia. Ketopatch 30 mg ketoprofen patch price, usage, dosage. Nonprescription ketoprofen is used to relieve minor aches and pain from headaches, menstrual periods, toothaches, the common cold, muscle aches, and backaches, and to reduce fever. The possibility of increased interaction should be kept in mind when orudis ketoprofen doses greater than 50 mg as a single dose or 200 mg of ketoprofen per day are used concomitantly with highly bound drugs. The objective of the present work was to obtain ph independent and improved dissolution profile for a poorly soluble drug, telmisartan using liquisolid compacts. Liquisols of ketoprofen were prepared using polyethylene glycol peg 400 as liquid vehicle, avicel ph 102 as carrier and aerosil 200 as coating material. Jan 07, 2020 ketoprofen is contraindicated for the treatment of perioperative pain in the setting of cabg surgery. Gel based liquisolid compact approach is an extreme case of viscosity enhancement that restricts the molecular motion of drug molecules, in which the movement. It is a propionic acid derivative and is a nonsteroidal antiinflammatory agent nsaia with analgesic and antipyretic properties. It was patented in 1967 and approved for medical use in 1980. Gel liquisolid compacts gls1gls10 and directly compressible tablets dct 1 and dct 2 of atorvastatin calcium were prepared and evaluated for flow properties, post compression parameters and in vitro dissolution studies. Liquisolid compacts are reported to be beneficial in enhancing, solubility 4, dissolution rate 5 and bioavailability 6 of poorly aqueous soluble drugs due to enhanced wetting properties. Twelve formulations of conventional tablets were prepared using liquisolid technique with nonvolatile solvent systems tween 80, propylene glycol and peg 400.

The prepared liquisolid compacts were evaluated for their flow. Formulation and evaluation of liquisolid compacts of ketoprofen using different dissolution enhancers and to study the effect of addition of various superdisintegrants on rate dissolution of ketoprofen. Curcumin 198, indomethacin 219, griseofulvin 205, loperamide 208, ketoprofen 220. Ketoprofen topical patch 20% in the treatment of pain. Because the patch facilitates delivery of ketoprofen over a 24hour period, the drug remains continually present in the tissue adjacent to the site of application. Transdermal adhesive patches loaded with ketoprofen evaluated. Topical application of ketoprofen improves gait disturbance. Formulation development of atorvastatin calciumtablets by. Then a standard calibration curve was constructed using ms excel as shown in fig 1. The limited solubility of drugs has always been a challenging task for pharmaceutical industries engaged in manufacturing and development of solid dosage forms. It acts by inhibiting the bodys production of prostaglandin it was patented in 1967 and approved for medical use in 1980.

The required quantities of ingredients for the compressible admixture were calculated using various mathematical models. The experimental runs or formulation design were based on box. A wide variety of ketoprofen plaster options are available to you, such as medicine grade, food grade. Development of liquisolid tablets of chlorpromazine using. Therefore, ketoprofen establishes a good candidate for testing the potential of rapidrelease liquisolid compacts. The liquisolid compacts were prepared with a varied quantity of liquid and powder ingredients using microcrystalline cellulose as a carrier, aerosil 200 as a coating material, polyethylene glycol 400, propylene glycol and tween80 as. In addition to this, studies have been conducted on the development of controlled or slow release delivery systems for systemic and local therapy of diseases in the oral cavity. There are 20 suppliers who sells ketoprofen plaster on, mainly located in asia.

Orudis capsules ketoprofen is rapidly and wellabsorbed, with peak plasma levels occurring within 0. Ketoprofen is a nonsteroidal antiinflammatory drug nsaid that works by reducing substances in the body that cause pain and inflammation. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Liquisolid technique is a new and promising method that can change the dissolution rate of drugs. The optimization of ketoprofen liquisolid compacts was carried out by taking into consideration the liquid load factor, amount of coating material and amount of magnesium oxide as formulation variables and the cumulative percentage drug releaset 100% in minutes and angle of repose. Formulation and characterization of ketoprofen liquisolid compacts by. Formulation and characterization of ketoprofen liquisolid compacts. The drug to be delivered is applied in high dose to the inside of the patch, which is sealed on the skin for long period of time 23 29. Preparation and characterization of liquisolid compacts. Various forms of kp are available in the pharmaceutical market.

The aim of the present investigation was to enhance the dissolution of poorly watersoluble drug ramipril bcs ii drug through liquisolid compact. Use of the liquisolid compact technique for improvement of the dissolution rate of valsartan. Formulation and characterization of ketoprofen liquisolid compacts by boxbehnken. Liquisolid compacts, phdependent solubility, boxbehnken design 1. Liquisolid technique is used in delivery of lipophilic and poorly water soluble drugs through oral route. Low aqueous solubility is one of the major reasons for the poor clinical efficacy of carvedilol in oral therapy. Comparison of single dose transdermal patches of diclofenac. The ketoprofen patches used in this study measured 7. Pharmaceutical dispersion techniques for dissolution and.

The ratio which showed the best release was considered as the optimized formulation. Furthermore, naproxen liquisolid tablets were prepared using polyethylene glycol 400 peg400 and microcrystalline cellulose avicel ph 101, silica gel and 5% sodium starch glycolate. List of drug master files dmf of ketoprofen active pharmaceutical ingredient api submitted to the u. Ketoprofen api dmfs us drug master file dmf details.

Jun 01, 2019 ketoprofen capsules usp should not be given to patients who have experienced asthma, urticaria, or allergictype reactions after taking aspirin or other nsaids. To overcome this problem, liquisolid technique has gained immense popularity as a novel approach in the last decade. Formulation and evaluation of transdermal patches of. Flurbiprofen is a member of the phenylalkanoic acid derivative family of nonsteroidal antiinflammatory drugs nsaids. Development of a novel ketoprofen transdermal patch 228 pak. Ketoprofen gel woodland hills compounding pharmacy. The release rate of ketoprofen from the drugaerogel formulation is much faster than that of the corresponding crystalline drugs.

Side effects of orudis ketoprofen, warnings, uses rxlist. Characterization of the prepared liquisolid compacts. The low bioavailability of crv is attributed to its lower solubility and extensive hepatic metabolism 3,4. In the topical group, two patches were applied to the skin of the thigh over the semitendinosus muscle fig. Ketoprofen is only found in individuals that have used or taken this drug. It is used to reduce swelling and to treat mild to moderate pain. It is practically insoluble in water, but is freely soluble in alcohol and ether. Oruvail capsules ketoprofen is also wellabsorbed from this dosage form, although an observable increase in plasma levels does not occur until approximately 2 to 3 hours after taking the formulation. Each nsaid ketoprofen, diclofenac, or loxoprofen, in the form of a gel or patch, was topically applied to the skin around the hind kneejoint before carrageenan injection. Physical characteristics, pharmacological properties and clinical. In the present study, liquid solid technique is used to enhance the bioavailability of ketoprofen. The present study deals with the dissolution enhancement of meloxicam by liquisolid technique. Formulation and evaluation of transdermal patch of aceclofenac.

Drug ketopatch 30mg 1 transdermal patch ketoprofen. Solubility enhancement of nifedipine using liquisolid. Vittal gv, deveswaran r, bharath s, basavaraj b, madhavan v. Experimental design of ketoprofen liquisolid compacts. Apply 24 times a day for up to 7 days, ketoprofen 2. Loxoprofen application did not show any improvement in gait, while ketoprofen dramatically improved gait disturbance figure 2a. Physicochemical and micromeritics properties of ketoprofentartaric. Design development of liquisolid compacts of atorvastatin calcium. Ketoprofen is a bcs class ii drug with poor aqueous solubility and limited its bioavailability. Introduction carvedilol crv is an antihypertensive. Abstact liquisolid compacts were used to formulate water insoluble drugs in non volatile solvents and convert into acceptable flowing compressible powders by blending with selected powder excipents. Formulation and estimation of rheological parameters of topical gels of ketoprofen. The dissolution profile and hardness of liquisolid compacts were not significantly. Ketoprofen is one of the propionic acid class of nonsteroidal antiinflammatory drugs nsaid with analgesic and antipyretic effects.

Formulation and characterization of ketoprofen liquisolid compacts by boxbehnken design. Aug 17, 2006 a phase iii study of the efficacy, tolerability and safety of the ketoprofen topical patch, 20% ktp in the treatment of pain associated with osteoarthritis flare of the knee, including a randomized, doubleblind, placebocontrolled, parallel group phase followed by an openlabel treatment phase. Jul 14, 2006 ketoprofen topical patch 20% in the treatment of pain associated with shoulder, elbow or knee tendonitis or bursitis the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. The antiinflammatory effects of ketoprofen are believed to be due to inhibition cylooxygenase2 cox2, an enzyme involved in prostaglandin synthesis via the arachidonic acid pathway. Antipyretic effects may be due to action on the hypothalamus, resulting in an. The ketoprofen concentrations in the dermis, subcutaneous tissue, and plasma were compared with the commercially available patch mohrus.

Pharmacokinetic data indicate that plasma levels of ketoprofen with oral. According to the new formulation method of liquisolid compacts, liquid medications such as solutions or suspensions of water insoluble drugs in suitable nonvolatile liquid vehicles, can be. Ketoprofen capsules are contraindicated in the setting of coronary artery bypass graft. Formulation and characterization of ketoprofen liquisolid. See what others have said about ketoprofen, including the effectiveness, ease of use and side effects. Based on the detection, pharmacokinetic parameters including c max, t max, and auc 08h were determined for both the formulations. This medication is a nonsteroidal antiinflammatory drug nsaid. It is primarily indicated as a preoperative antimiotic in an ophthalmic solution as well as orally for arthritis or dental pain. It involves dissolving water insoluble drugs in nonvolatile. The dissolution behavior of loratadine from liquisolid compacts was.

Find patient medical information for ketoprofen bulk on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Liquisolid compacts liquisols are the solid dosage forms with. Identification of the substancemixture and of the companyundertaking. Different liquisolid compacts were prepared using a mathematical model to calculate the required quantities of powder and liquid ingredients to produce acceptable and free flowing compressible mixtures. Physical characteristics, pharmacological properties and clinical efficacy of the ketoprofen patch. Ketoprofen is a nonsteroidal antiinflammatory drug nsaid. Liquisolid compacts were prepared using transcutol hp as vehicle, avicel ph102 as carrier, and. Drug ketoplast 20mg 7 transdermal patch ketoprofen. Ketoplast 20mg 7 transdermal patch ketoprofen drug information. Ketoprofen, 100 mg, has been tried as a patch to directly deliver the compound to the site of injury. Nsaids can also cause an increased risk of serious gastrointestinal adverse events especially in the elderly, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.

It also reduces pain, swelling, and joint stiffness from arthritis. Ketoprofen transdermal patches in various doses have been found to be more effective than placebo in both traumatic and non traumatic pain without any additional side effects. The xrd patterns of ketoprofen raw material and solid dispersion 1. Pharmacokinetic data indicate that although plasma levels of ketoprofen are higher when the drug is administered as a patch versus a gel, the total systemic bioavailability of ketoprofen 100mg administered via a patch is no more than 10% of that reported for ketoprofen 100mg administered orally. Find its price or cost, dose, when to use, how to use, side effects, adverse effects, substitutes. The main active ingredient or salt in this drug is ketoprofen. Ketoprofen is thought to have antibradykinin activity, as well as lysosomal membranestabilizing action. Structural analysis of gls was done using differential scanning calorimetry dsc and x ray powder diffraction xrd.

Materials and methods determination of solubility solubility studies of ketoprofen were carried out in water, phosphate buffer 7. Enhancement of ketoconazole dissolution rate by the liquisolid. This medicine may be used to treat osteoarthritis and rheumatoid arthritis, or painful monthly periods. Moreover, the topical ketoprofen patch was well tolerated. Currents were studied using the wholecell configuration of the patch clamp technique. The incidence of common adverse reactions above 1% was obtained from a population of 835 orudis ketoprofen treated patients in doubleblind trials lasting from 4 to 54 weeks and in 622 oruvailtreated 200 mgday patients in trials lasting from 4 to 16 weeks. Ketoprofen has analgesic, antiinflammatory, and antipyretic properties, and it is an inhibitor of cyclooxygenase. Indomethacin 219, griseofulvin 205, loperamide 208, ketoprofen 220. Formulation and evaluation of ketoprofen by liquisolid. A wide variety of ketoprofen plaster options are available to you, such as grade standard.

Pdf investigating the use of liquisolid compacts technique to. Design and evaluation of matrix diffusion controlled transdermal patches of. Ketoprofen works by reducing hormones that cause inflammation and pain in the body. The objective of the present investigation was to formulate and evaluate the mouth dissolving tablets mdts of ketoprofen kpn using disintegrants like crospovidone cp, croscarmellose sodium ccs and sodium starch glycolate ssg and the effect of disintegrants on drug release was also studied. It acts by inhibiting the bodys production of prostaglandin. The aim of the present investigation was to evaluate the potential of liquisolid compact technique to enhance the dissolution rates of carvedilol and thereby the bioavailability. Ketoprofen is in a class of medications called nsaids. Brian birmingham, asokumar buvanendran, in practical management of pain fifth edition, 2014. It was derived from propionic acid by the research arm of boots uk during the 1960s, a period. It was concluded that ketoprofen in the liquisolid system was in a molecular form and no crystallinity or interaction were observed between ketoprofen and excipients. Rjpdft research journal of pharmaceutical dosage forms and. Javadzadeh y, mohammed r, solamaz a,ali n, evaluated the effects of different grades of microcrystalline cellulose on flowability, compressibility and dissolution.

Severe, rarely fatal, anaphylactic reactions to ketoprofen have been reported in such patients. Transdermal drug delivery systems open access journals. Ketopatch 30mg 1 transdermal patch ketoprofen drug information. Due to low systemic passage of ketoprofen from the gel such safety data are not relevant for local administration. The following drug interactions were studied with ketoprofen doses of 200 mgday.

Both natural and synthetic polymers are used for the preparation of mucoadhesive buccal patches. Ketopatch 30 mg ketoprofen drug brand ketopatch 30 mg is being manufactured and marketed by emcure pharmaceuticals ltd. Development and evaluation of time controlled release tablet of. Avicel ph 102, aerosil200 were employed as carrier and coating materials. Full text ketoprofenloaded polymer carriers in bigel formulation.

The target organs for chronic toxicity are the gastrointestinal tract, the kidney and, to a lesser degree the liver. Ketoprofen fda prescribing information, side effects and uses. Liquisolid compacts demonstrated significantly higher drug release rates, in different dissolution media and volumes, compared to tablet prepared by the direct compression method10. Our compounded gels and creams are used to help with mild to moderate pain, or signs and symptoms of osteoarthritis or rheumatoid arthritis. Nsaids can also cause an increased risk of serious gastrointestinal adverse events especially in the elderly, including bleeding, ulceration, and. Development of a novel ketoprofen transdermal patch. Liquisolid compacts were prepared using polyethylene glycol 400, neusilin us2 and aerosil 200. Ketoprofen is a nonspecific cyclooxygenase inhibitor and inhibition of cox1 is thought to confer some of its side effects, such as gi upset and ulceration.

Formulation and characterization of ketoprofen liquisolid compacts by box behnken. The aim of the study was to compare the efficacy and safety of transdermal patch of ketoprofen in comparison to diclofenac patch for postoperative analgesia. Liquisolid compact tablets or capsules can be obtained after lipid dispersions are. As this emedtv page explains, ketoprofen is a drug used to treat pain, inflammation, and swelling caused by several conditions. Nov 09, 2018 ketoprofen is a nonsteroidal antiinflammatory drug nsaid. Liquid solid compact technology is a novel approach to enhance. It suffers a low absolute bioavailability in humans approximately 30%. The experimental runs or formulation design were based on boxbehnken designs using response surface methodology and utilized to evaluate the response variables. This page also describes possible side effects and general precautions. Ketoprofen is metabolised by the liver and excreted by the kidneys and, as such, it is dialyzable. Formulation and invitro evaluation of mouth dissolving. Identification of the substancemixture and of the companyundertaking product name. Results and discussion effect of vehicle type on the release of ketoprofen at different ph the release of ketoprofen from formulas f1, f2, and f3, which are formulated using pg, tween80 and peg as a vehicle respectively is shown in figure 1. Currents were studied using the wholecell configuration of the patchclamp technique.

About 23% of these are vitamins, amino acids and coenzymes, 23% are antibiotic and antimicrobial agents, and 19% are antipyretic analgesics and nsaids. Ketoprofen is used to relieve pain from various conditions. The general packing available for this medicine consists of 1 patch and is priced at rs 19. Another 10 patients served as the control group and were not given any drug. Ketoprofen absorption by muscle and tendon after topical. Studies on the local tolerance have shown that ketoprofen is well tolerated.

The top countries of suppliers are china, south korea, from which the percentage of ketoprofen plaster supply is 90%, 10% respectively. It works by stopping the bodys production of a substance that causes pain, fever, and inflammation. Improvement of oral bioavailability of carvedilol by. Formulation development of atorvastatin calcium tablets by. The liquisolid compacts were prepared with a varied quantity of liquid and powder ingredients using microcrystalline cellulose as a carrier, aerosil 200 as a coating material, polyethylene glycol 400, propylene glycol and tween80 as liquid vehicles, hpmc as additives to increase loading capacity. Although the solubility of ketoprofen was found to be higher in propylene glycol pg compared to tween 80 112. Ketoprofen gel produces plasma levels that are about 60% lower than those experienced after a single oral dose of ketoprofen.

Transdermal patch or adhesive patch or skin patch used to deliver a controlled dose of a drug through the skin over a period of time. When applied topically it reduces pain receptor sensitivity. Nifedipine as a long and shortacting 1,4dihydropyridine calcium channel blocker. Ketoprofen topical patch, 20% in the treatment of pain. Ketoprofen side effects, dosage, interactions drugs. A transdermal patch or a skin patch is a medicated adhesive patch that is adhered to the skin to transport a specific dose of medication through skin into the circulation. Ketoprofen gel ketoprofen, ketoprofen gel products.